The Biochemistry and Physiology of Vitamin D. Regulation of Vitamin D Metabolism and Function. The Story of Vitamin D, from Vitamin to Hormone. This process is experimental and the keywords may be updated as the learning algorithm improves. These keywords were added by machine and not by the authors. On the other hand, if the same animals are placed on a low phosphorus diet in the absence of vitamin D, the classical symptoms of rickets develop (1). ![]() The best example is the experimental rat which, when placed on a low calcium diet in the absence of vitamin D, does not develop the classical signs of rickets or even osteomalacia, but rather develops hypocalcemic tetany and a disease more like osteoporosis (1). Although correct, this concept is too narrow to encompass the pathological states which are known in experimental animals suffering vitamin D deficiency. ![]() It is common belief among scientists, clinical scientists and practicing physicians that a deficiency of vitamin D brings about either the disease osteomalacia or the disease rickets, both of which are characterized by failure of mineralization of organic matrix of newly synthesized bone.
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